Because Kids Can’t Fight Alone, and Neither Does CLF
Synergy (noun) interaction or cooperation of two or more organizations to produce a combined effect greater than the sum of their separate effects.
The Carson Leslie Foundation (CLF) believes in synergy/collaboration/working together & directing funds.
Because of unique relationship CLF has with The Cancer Prevention and Research Institute of Texas (CPRIT), CLF’s funds are tremendously leveraged.
This unique opportunity is a privilege so together, with synergy; we’re helping to stimulate great scientific thinking within childhood brain cancer research in our Great State of Texas.
Although our research stays in Texas; results, of course, are shared with the world.
Leveraging and directing funds is smart—Every dollar we raise is able to make a much greater impact.
Carson Leslie Awards for Pediatric Brain Cancers, a result of a unique relationship between CLF and The Cancer Prevention and Research Institute of Texas (CPRIT) we’re pleased to fund over $3,200,000.00 in research for less toxic childhood brain cancer treatments.
As of May 2018 all 3 studies have ended and we are expecting published results very soon!
The University of Texas Southwestern Medical Center
Genotype and Metabolic Phenotype in Pediatric Brain cancer
Baylor College of Medicine
Proton Beam Radiation Therapy vs. Conventional Beam Radiation Therapy Toxicities During and after Craniospinal Radiation Therapy in Children
Texas Tech University Health Science Center (actually using tumors from Carson)
Rational Redox-Driven Non-Toxic Therapeutic Strategies for Pediatric Brain Cancers
We’ll follow these studies and post results of exciting discoveries made—stay tuned
More CLF SYNERGY:
- Write for The American Cancer Society pediatric pamphlets
- Host a bipartisan Congressional Childhood cancer Caucus event in D.C.
- Spoke at Hyundai’s Hope on Wheels Gala in D.C.
- Discussing with National Brain Tumor Society to collaborate in Pediatric Brain cancer Research
“Texas voters overwhelmingly approved a constitutional amendment in 2007 establishing the Cancer Prevention and Research Institute of Texas (CPRIT) authorizing the state to issue $3 billion in bonds to fund groundbreaking cancer research and prevention programs and services in Texas.”
“CPRIT promises to maintain the highest integrity and dedication to the mission of finding a cure for cancer. CPRIT’s objective is to position Texas as a world-class leader in research and prevention through collaboration with a variety of entities, including public and private institutions of higher education, academic health institutions, universities, governmental organizations, nongovernmental organizations, public and private companies and others involved in the fight against cancer.” —CPRIT
Annette Leslie has the humble privilege of serving on CPRIT’s Childhood cancer Advisory Council.
Leveraging funds and collaboration allows every donation to make a much greater impact.
Synergy: cooperation of two or more organizations to produce a combined effect greater than the sum of their separate effects.
The Carson Leslie Awards a $3,200,000 CPRIT/CLF collaborative investment!
RP130266 PI, Srivenugopal, Kalkunte; Rational redox-driven non-toxic therapeutic strategies for pediatric brain cancers (Carson Leslie Award)
The anti-mutagenic DNA repair protein MGMT is highly expressed in pediatric brain cancers. It is a major target to improve the efficacy of anti-glioma alkylating agents. O6-benzylguanine, an MGMT inhibitor is currently in clinical trials; however, the results have been disappointing due to extended bone marrow suppression. Our studies have shown that compounds like disulfiram and nitroaspirin potently inhibit MGMT and improve the alkylator efficacy in cell culture and xenograft models.
RP130368 PI, Ris, M Douglas; Proton Beam Radiation Therapy vs. Conventional Beam Radiation Therapy: Toxicities During & After Craniospinal Radiation Therapy in Children (Carson Leslie Award)
Toxicities resulting from the treatment of pediatric brain tumors have significant quality of life implications for survivors. This project is assessing the comparative, short-termtoxicities of two types of radiotherapy – conventional X-ray therapy and proton beam radiotherapy. More information about the toxicities associated with radiotherapy will allow serve as the basis for the development of strategies to minimize the short and long term effects of radiotherapy as part of our goal to promote better overall outcomes in survivors.
RP130629 Maher, Elizabeth A; Genotype and Metabolic Phenotype in Pediatric Brain Cancer (Carson Leslie Award)
Research update is forthcoming
Thank you for helping us fight for the smallest and most innocent cancer patients & honoring Carson’s wish.
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